Active ingredient: bupropion. Available generic and brand. Pictured here 150mg generic bupropion.
Usually prescribed for depression, can also be prescribed for weight loss, smoking cessation aide, also for ADHD. Marketed as Wellbutrin,Budeprion, Prexaton, Elontril, Aplenzin. Marketed in lower-dose formulations as Zyban, Voxra, or other names, it is also widely used to reduce nicotine cravings by people who are trying to quit smoking. It is taken in the form of pills, and in the United States is available only by prescription.
Bupropion serves as a non-tricyclic antidepressant fundamentally different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors (SSRIs). It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. In contrast to many other antidepressants, it does not cause weight gain or sexual dysfunction. The most important side effect is an increase in risk for epileptic seizures, which caused the drug to be withdrawn from the market for some time and then caused the recommended dosage to be reduced. 300 mg a day (for average body weight) has been shown to maintain the same 0.1% unprovoked seizure rate of the general population.
Bupropion affects a number of neurotransmitter systems, and its mechanisms of action are only partly understood. The primary pharmacological action of the drug is as a mild dopamine reuptake inhibitor and also a much weaker norepinephrine reuptake inhibitor as well as a nicotinic acetylcholine receptor antagonist. Chemically, bupropion belongs to the class of aminoketones and is similar in structure to stimulants such as cathinone and amfepramone, and tophenethylamines in general.
Bupropion was patented in 1969 by Burroughs Wellcome, which later became part of what is now GlaxoSmithKline. It was originally called amfebutamone, before being renamed in 2000. Its chemical name is 3-chloro-N-tert-butyl-β-ketoamphetamine. It is a substituted cathinone (β-ketoamphetamine), as well as a substituted amphetamine.
Unlike other anti-depressants bupropion is a mild stimulant and is often used along with SSRIs to counter the negative side effects and also provide some more energy. Because it is a stimulant it is ripe for abuse. In Toronto Canada, this is used as a cheap substitute for cocaine. And junkies shoot bupropion. Injected it is very dangerou8s as it will produce severe skin disease and scabs that never heal. In American prisons these pills are sold for $2 to $5 each. Some people who have been prescribed buptopion have discovered if you scratch of the outer coating of the pill and then crush it to a fine powder, it can be snorted with little nose burn and provides a brief euphoric rush. Unfortunetely there is a roof on this “high”. After you reach the roof, no matter how much more you take won’t get you any higher and will keep you up for the next 2 days.
Another popular method is to either take bupropion orally with alcohol to increase the effects of being drunk and stimulated at the same time, or snort small lines with shots. What makes this so addicting is it creates a dependency to abuse with alcohol and or other narcotics or drugs. You can also cut real cocaine with bupropion to increase your quantity with minimum degrade in quality. Many found this to be a great way to express an existing addiction to porn. Since it can keep you up for longer periods. Breaking this habit is very possible with minimum difficulty, very little withdrawal and it’s all psychological. But very doable!
What makes this drug a real problem is it can effect your normal routine and life and produce severe mood swings and depression. It also increases the risk of seizures significantly. Usually mild however can not rule out severe.
There is no addicting characteristics in Bupropion. It is a safe alternative to amphetamines however is still very abusable despite it’s roof. It can and does increase the effects of other drugs making it a popular addition for almost any thing. There are no long term studies done on snorting bupropion or orally abusing it with other substances. We do know shooting it is extremely harmful immediately. In other words, no one should consider this a safe alternative for recreational use. And can very well be even more dangerous long term then abusing benzodiazepines, which in my opinion is safer then Bupropion.